Reduced serum vitamin B-12 in patients taking metformin.

نویسندگان

  • Josep Vidal-Alaball
  • Christopher C Butler
چکیده

Josep Vidal-Alaball honorary research fellow [email protected] Christopher C Butler professor of primary care medicine, Department of Primary Care and Public Health, Heath Park, Cardiff CF14 4YS Competing interests: All authors have completed the Unified Competing Interest form at www.icmje.org/coi_disclosure. pdf (available on request from the corresponding author) and declare: (1) No financial support for the submitted work from anyone other than their employer; (2) No financial relationships with commercial entities that might have an interest in the submitted work; (3) No spouses, partners, or children with relationships with commercial entities that might have an interest in the submitted work; (4) No non-financial interests that may be relevant to the submitted work.” Provenance and peer review: Commissioned; not externally peer reviewed.

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منابع مشابه

Vitamin B12 in metformin-treated diabetic patients: a cross-sectional study in Brazil.

OBJECTIVE The objective of this study was to evaluate the presence of vitamin B12 deficiency and the factors associated with serum vitamin B12 levels in a sample of metformin-treated Brazilian diabetic patients. METHOD Cross-sectional study. RESULTS 144 patients were included. Serum vitamin B12 levels were low (< 125 pmol/L) in 10 patients (6.9%) and possibly low (125 - 250 pmol/L) in 53 pa...

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Vitamin B12 deficiency and the lack of its consequences in type 2 diabetes patients using metformin.

OBJECTIVES To study vitamin B12 concentrations in patients with type 2 diabetes with and without metformin use and to identify risk factors and consequences of low vitamin B12 concentrations. RESEARCH DESIGN AND METHODS This study had a cross-sectional design. During eight weeks all patients with type 2 diabetes visiting the diabetic outpatient clinic of the Isala Clinics in Zwolle were appro...

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Vitamin B12 Levels in Patients with Type 2 Diabetes Mellitus on Metformin.

BACKGROUND Due to the clinical benefits of metformin, its associated side effects such as vitamin B12 deficiency are usually overlooked and rarely investigated. OBJECTIVE This study was carried out to determine the serum level of vitamin B12 in Nigerian patients with type 2 diabetes mellitus (T2DM) on metformin. METHODS Serum vitamin B12 level was determined using high performance liquid ch...

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Association between metformin and vitamin B12 deficiency in patients with type 2 diabetes: A systematic review and meta-analysis.

AIM Metformin is the most widely used oral hypoglycaemic drug, but it may lower B12 status, which could have important clinical implications. We undertook a systematic review and meta-analysis of the relationship between metformin use and vitamin B12 deficiency in persons with type 2 diabetes. METHODS Electronic database searches were undertaken (1st January 1957-1st July 2013) using the Coch...

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Vitamin B12 Deficiency Associated With Concomitant Metformin and Proton Pump Inhibitor Use

M etformin and proton pump in-hibitors have been implicated in decreasing levels of vitamin B 12 independently. The purpose of this study was to evaluate the effect of concomitant use of metformin and proton pump inhibitors on the incidence of vitamin B 12 deficiency. A retrospective chart review was done using the computerized patient record system at the Memphis VA Medical Center for 614 pati...

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عنوان ژورنال:
  • BMJ

دوره 340  شماره 

صفحات  -

تاریخ انتشار 2010